A Limited Vs a Transient AT1R Internalization Indicates that Distinct Mechanisms of AT1R Activation are Possible
نویسندگان
چکیده
منابع مشابه
p100 increases AT1R expression through interaction with AT1R 3′-UTR
p100 protein (SND1, Tudor-SN) is a multifunctional protein that functions as a co-activator for several transcription factors, has a role in mRNA processing and participates in RNAi-induced silencing complex (RISC) with yet unknown function. In this study we identified a novel function for p100 as a regulator of angiotensin II type 1 receptor (AT1R) expression. The binding of p100 to AT1R 3'-un...
متن کاملNeuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation.
PURPOSE To investigate the retinal neural damage that occurs during inflammation and the therapeutic effects of the angiotensin II type 1 receptor (AT1R) blocker, telmisartan, using a model of endotoxin-induced uveitis (EIU). METHODS The localization of AT1R and AT2R was shown by immunohistochemistry. EIU was induced by intraperitoneal injection of lipopolysaccharide (LPS). Animals were treat...
متن کاملRegulation of AT1R expression through HuR by insulin
Angiotensin II type 1 receptor (AT1R) has a pathophysiological role in hypertension, atherosclerosis and heart failure. Type 2 diabetes is hyperinsulinemic state and a major risk factor for atherosclerosis and hypertension. It is known that hyperinsulinemia upregulates AT1R expression post-transcriptionally by increasing the half-life of AT1R mRNA, but little is known about the mechanism of thi...
متن کاملAT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II
As you can see below, the referees express an interest in the study, but also raise many different concerns with the data and the conclusions drawn. One main concern raised is that the data provided do not sufficiently support the conclusion that ATR1-CB1R receptor heteromerization mediates the observed signaling potentiation. Another explanation could also be that functional crosstalk between ...
متن کاملAT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II.
The mechanism of G protein-coupled receptor (GPCR) signal integration is controversial. While GPCR assembly into hetero-oligomers facilitates signal integration of different receptor types, cross-talk between Gαi- and Gαq-coupled receptors is often thought to be oligomerization independent. In this study, we examined the mechanism of signal integration between the Gαi-coupled type I cannabinoid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.05053